肝细胞_____NFκB；_基因，Bcl2

核因子κB, Bcl2在肝癌的表达及其相关性

http://www.100md.com 《第四军医大学学报》 2004年第10期

肝细胞,,NFκB；,基因，Bcl2,；脱噬作用；癌，肝细胞;,免疫组织化学,核因子κB,Bcl2在肝癌的表达及其相关性,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Expression of NFκB in human hepatocellular carcinoma and its relation to Bcl2 expression

    ZHANG YuHong, DOU KeFeng

    Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To explore NFκB expression in liver carcinoma tissues and its correlation with the pathological stage of cancer tissues and the expression of Bcl2. METHODS: By means of immunohistochemical SABC method, the expressions of NFκB and Bcl2 were compared between the hepatocellular carcinoma tissues from 40 cases and normal liver tissues from 15 cases. RESULTS: The positive expression and the strong positive expression of NFκB in the liver cancer group and the control group were 72%, 13% (P<0.01) and 30%, 7% (P<0.05) respectively, both with significant difference. The positive expression and strong positive expression of Bcl2 were 40%, 7% (P<0.05) and 17%, 0 respectively. The positive expression of NFκB was significantly different for different pathological grades (P<0.01) and the expression of Bcl2 was closely related to NFκB (r=0.389, P=0.013). CONCLUSION: The abnormal expression of NFκB is closely associated with the development of liver cancer and the expression of NFκB is significantly different for different pathological grades. NFκB is closely related to Bcl2, which indicates that NFκB is involved in the antiapoptosis of liver cancer cell by mediating antiapoptosis gene. ......

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