血管瘤_____血管瘤；Ang2

原位RTPCR检测血管瘤组织Ang2 mRNA及其受体Tie2 mRNA的表达

http://www.100md.com 《第四军医大学学报》 2004年第11期

血管瘤,,血管瘤；Ang2,mRNA；Tie2,mRNA；原位RTPCR,原位RTPCR检测血管瘤组织Ang2mRNA及其受体Tie2mRNA的表达,0引言,1材料和方法,2结果,3讨论,【

     In situ RTPCR detection of Ang2 mRNA and Tie2 mRNA expression in hemangioma

    XU Quan, MENG BaoYing, DANG ShuangSuo, LI Peng, LIU Bin, DUAN YiTao

    1Department of Pediatric Surgery, 2Department of Infectious Diseases, Second Hospital, Xi’an Jiaotong University, Xi’an 710004, China

    【Abstract】 AIM: To investigate the relationship between Ang2/Tie2 and the growth of hemangioma and venous vascular malformation. METHODS: Sixtytwo cases of specimens collected in operation were studied by in situ RTPCR, of which 50 cases were hemangioma: 26 cases proliferating hemangioma and 24 cases involuting hemangioma, and 12 cases were venous vascular malformation. The expression of Ang2 mRNA and Tie2 mRNA in hemangiomas and venous vascular malformation were detected by in situ RTPCR. RESULTS: The results showed that Ang2 mRNA and Tie2 mRNA were expressed in proliferating hemangioma, involuting hemangioma and venous vascular malformation, but the expression of Ang2 mRNA and Tie2 mRNA in venous vascular malformation was lower than that in proliferating and involuting hemangioma. The expression of Ang2 mRNA and Tie2 mRNA in proliferating hemangioma was higher than that of involuting hemangioma (P﹤0.01). CONCLUSION: It can be concluded from the results that there is an close relationship between Ang2 /Tie2 system and hemangiomas and venous vascular malformation. ......

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