p16蛋白及其基因在原发性肝细胞癌中的表达缺失及意义
肝细胞癌,,肝细胞癌;,基因缺失;,p16蛋白,0引言,1材料和方法,2结果,3讨论,【参考文献】
A study on p16 protein expression and p16 gene deletion in primary hepatocellular carcinomaHE XianLi, MA QingJiu, LU JianGuo, LI GuangYu
1Department of General Surgery, 2Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
【Abstract】 AIM: To study the p16 protein expression and p16 gene deletion in hepatocellular carcinoma (HCC) and to evaluate the relationship between p16 gene and HCC. MEHTODS: The expression of p16 protein and the deletion of p16 gene were detected by immunohistochemistry and polymerase chain reaction (PCR) in 32 cases of HCC. RESULTS: The loss of p16 protein expression was observed in 20 cases of HCC (62.5%, 20/32) and in 1 case of tumor adjacent tissues (3.13%, 1/32), respectively (P<0.01). The loss of p16 protein expression was closely correlated with the poor histological differentiation of the tumor (P<0.01). The deletion rate of p16 gene in HCC (25%,8/32) was significantly different from that in tumor adjacent hepatic tissues (3.13%, 1/32, P<0.05). CONCLUSION: There is a close relationship between hepatocarcinogenesis and p16 gene inactivation. The expression of p16 protein can be used as an index in predicting the prognosis. ......
您现在查看是摘要页,全文长 7226 字符。