Clinical analysis of 15 cases of staphylococcal scalded skin syndrome

    FAN Pingª²Shen, LIAO Wenª²Jun, GAO Tianª²Wen, Wang Yan, LI Chunª²Ying, Hu Xueª²Hui

    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To review the clinical characteristics and treatment of staphylococcal scalded skin syndrome (SSSS) and to explore its mechanisms. METHODS: Fifteen inpatients (aged 8 months to 5 years) with SSSS from May 1995 to October 2003 were retrospectively analyzed, which included their clinical presentation, treatment and efficacy. RESULTS: All cases were presented with actinomorphic cracks in oral pheriphery, skin erythema, epidermis exfoliation and tenderness and Nikolsky sign was positive in all the patients. Ten of thirteen cases showed positive staphylococus aureus growth in involved area and Methicillinª²resistant St. aureus (MRSA) were isolated from four cases. White blood cell count of eight cases exceeded 10¡Á109/L and histopathological sections from seven cases showed blister with acantholytic keratinocytes in upper layer of epidermis. All the cases improved greatly two or three days after sensitive antibiotics administration and five or six days after treatment, all the patients were discharged from the hospital, with lesions vanishing completely. CONCLUSION: SSSS tends to affect infants. Methicillinª²resistant staphylococcus infection should take into consideration in the pathogenesis of SSSS. Early administration of sensitive antibiotics, lesions protection and secondary infection prevention are important in the treatment of SSSS. ......