A mathematical model of inositol phospholipid hydrolyzed by PLC in mouse fibroblasts

    SU Yongª²Chun, LU Di, DENG Fan, BAI Xiaoª²Chun, LUO Shenª²Qiu, DENG Qinª²Kai

    1Department of Medical Physics, 2Department of Cell biology, First Military Medical University, Guangzhou 510515, China

    ¡¾Abstract¡¿ AIM: To establish a mathematical model of inositol phospholipid hydrolyzed by phospholipase C in mouse fibroblasts. MEHTODS: Based on the cellular signal transduction and the Law of the Quasiª²Steadyª²State Approximation, the metabolizability of inositol phospholipid was simulated by making use of mathematical model of differential equations. RESULTS: Differential equations of concentration relations were formulated between inositol phosphate and epidermal growth factor receptor, and the hydrolysable rate was demonstrated in these differential equations. CONCLUSION: This mathematical model describes the biological characteristics and the concentration relations between the key products during the hydrolyzation of inositol phospholipid. The effect of parameters on the mathematical model has been discussed and the consumption of inositol phospholipid by Ras/extracellular signalª²regulated kinase and phosphatidylinositol 3ª²kinase pathways has been analyzed. ......