聚酶链反应__(期刊论文)

西安地区汉族亚甲基四氢叶酸还原酶的两种基因多态性

http://www.100md.com 《第四军医大学学报》 2003年第7期

聚酶链反应,,限制性片段长度多态性；亚甲基四氢叶酸还原酶；基因，聚酶链反应,0引言,1对象和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院：神经内科，检验科，陕西西安 710033)

    Two genetic polymorphisms of 5, 10methylenetetrahydrofolate reductase among the Han people in Xian area

    SUN WenPing,WAN Qi, SU MingQuan

    Department of Neurology, Department of Laboratory, Xijing Hospital,Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To find out two genetic polymorphisms of MTHFR among the Han people in Xian area. METHODS: PCRRFLP technique was used to detect C677T and A1298C polymorphisms of MTHFR. RESULTS: The allele frequencies of 677T and 1298C were 45% and 20%, respectively and the homozygote frequencies of 677TT and 1298CC were 18% and 3%, respectively. The frequence of combined heterozygosity for the C677T and A1298C mutations was 21%. CONCLUSION: The genetic polymorphism of MTHFR from our study is different from those previously reported by others, which may due to differences between populations. ......

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