神经胶质_细胞学_____Nogo66受体；神经胶质

Nogo66受体在成年大鼠脊髓白质内胶质细胞的分布

http://www.100md.com 《第四军医大学学报》 2004年第16期

神经胶质,细胞学,,Nogo66受体；神经胶质,细胞学；缝隙接合部；显微镜检查，电子；显微镜检查，共焦,0引言,1材料和方法,2结果,3讨

     Distribution of Nogo66 receptor in glial cells of white matter in adult rat spinal cord

    HU ZeLan, LIU YingYing, JIN WeiLin, LIU HuiLing, JU Gong

    PLA Institute of Neurosciences, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the distribution of Nogo66 receptor (NgR) protein in the white matter of the adult rat spinal cord. METHODS: Adult male SpragueDawley rats were sacrificed to get the spinal cord. Immunohistochemical studies with light microscopy, confocal microscopy and electron microscopy were conducted to examine the distribution of NgR protein in the white matter of the adult rat spinal cord. RESULTS: At light microscopic level, NgR immunopositive fine spots could be identified, mainly at the periphery of the glial cell body and along their processes and seemingly in close relationship to the cell membrane. Ultrastructurally, the NgR immunopositive gold particles were localized at the gap junctions between astrocytes, between oligodendrocytes, or between astrocyte and oligodendrocyte. CONCLUSION: The present work provides morphological evidence for the presence of NgR in glial cells of adult rat spinal cord and its localization at the gap junctions, which indicates its possible modulatory function in glial intercellular communication. ......

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