萎缩性胃炎_____热盐水；萎缩性胃炎；超微结构

热盐水致大鼠萎缩性胃炎胃黏膜超微结构的变化

http://www.100md.com 《第四军医大学学报》 2004年第19期

萎缩性胃炎,,热盐水；萎缩性胃炎；超微结构,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Ultrastructural changes of gastric mucosa in atrophic gastritis rat model caused by highsalthot water

    ZHANG Li，WANG ChunMei，TAO Mei, ZHANG LingXia，JIANG Mei，CAO GuangZhou

    1Department of Gastroenterology, Xi’an Municipal Central Hospital, Xi’an 710003, China，2Center of Electron Microscopy, School of Basic Medicine, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To observe the ultrastructure diversification of gastric mucosa in atrophic gastritis rat model caused by highsalthot water and to study the pathogenesis of atrophic gastritis caused by highsalthot diet. METHODS： The atrophic gastritis rat model was made by highsalthot water(55℃，150 g/mL, 2.5 mL/d, for 32 weeks)perfusion and the ultrastructure of gastric mucosa was observed by transmission electromicroscope. RESULTS： In the early stage of highsalthot water perfusion, the swell of mitochondrion, dilation of rough endoplasmic reticulum and short or lost of microvillus were observed in gastric mucosa. With the passage of time, the structure of mitochondrion became blurring, the endoplasmic reticulum dilated notably and microvillus lost significantly. CONCLUSION： Highsalthot water perfusion may cause ultrastructural damage in gastric mucosa. ......

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