脑胶质瘤_____整合素β1；脑胶质瘤；免疫组化；原位杂交

整合素β1亚基表达与人脑胶质瘤侵袭与复发的关系

http://www.100md.com 《第四军医大学学报》 2003年第7期

脑胶质瘤,,整合素β1；脑胶质瘤；免疫组化；原位杂交,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院全军神经外科研究所，陕西西安 710033)

    Expression and clinical significance of integrin β1 gene in human glioams

    ZHANG Xiang， WU JingWen, GUO Yan, FU LuoAn, GAO DaKuan

    Institute of Neurosurgery of Chinese PLA, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To detect the expression of integrinβ1 gene in human gliomas and analyze its clinical significance. METHODS: The expression of integrinβ1 gene in 53 pieces of gliomas was detected by immunohistochemical and hybridization technique in situ. The patients were followed up and their prognosis was compared. RESULTS: The positive rate of Integrinβ1 in gliomas of grade I to Ⅳ was 36.3%, 38.5%, 72.2% and 81.8% respectively. The integrinβ1 positive rate in gliomas of grade Ⅲ and Ⅳ was higher than that of grade I and Ⅱ (P<0.05). The integrinβ1 mRNA expression in gliomas was positively correlated with its protein expression. Patients with higher expression of integrinβ1 had poorer prognosis and shorter survival time. CONCLUSION: The higher expression of integrinβ1 is closely related with the lower differentiation and higher invasiveness of gliomas. Integrinβ1 may be a good indicator in predicating the prognosis of gliomas patients. ......

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