Detection of serum ILª²1¦Â, ILª²6 concentrations in cases of Alzheimer¬ðs disease and its significance

    GUO Feng, QU Qiuª²Min, Han Jianª²Feng, QIAO Jin, YANG Hua, WU Chengª²Bin

    Department of Neurology, First Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To explore the changes of serum interleukinª²1¦Â(ILª²1¦Â) and interleukinª²6 (ILª²6) in patients with Alzheimer's disease (AD) and their relationship with the degree of AD. METHODS: Following 1¡Ã1 matched pairing principle, 28 AD patients and 28 normal controls were enrolled in the study. The serum ILª²1¦Â and ILª²6 levels were determined by enzymeª²linked immunosorbent assay (ELISA). RESULTS: The content of serum ILª²1¦Â in the cases of AD (24¡À13 ng/L) was higher than that in the normal controls (NC) (7¡À5 ng/L) and there was significant difference between the two groups(P<0.01)but there was no significant difference in the content of ILª²6 between the two groups(P>0.05). There was no significant difference in serum contents of ILª²1¦Â, ILª²6 between patients with different degree of AD(P>0.05). CONCLUSION: The content of serum ILª²1¦Â in AD cases is higher than that in NC, which may correlate with the inflammation in brains of AD cases. The relationship between peripheral ILª²6 level and the inflammatory process in brains of AD cases needs further study. ......