基因频率_____HLA抗原；(期刊论文)

西安地区HLA DR抗原分布特征及分型方法的比较

http://www.100md.com 《第四军医大学学报》 2004年第16期

基因频率,,HLA抗原；,多态现象(遗传学)；基因频率,西安地区HLADR抗原分布特征及分型方法的比较,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Distribution of HLA-DR antigen in Xian area and comparison of typing methods

    LIU MengLi, ZHANG Yan, LIU Sheng, WANG Bo

    1Department of Blood Type, Shaanxi Blood Center, Xian 710061, China, 2Department of Epidemiology, School of Preventive Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To find out the distribution characteristics of HLADR antigen in the population of Xian and to compare the typing efficacy of different experimental methods. METHODS: Polymerase chain reaction with sequence specific primer (PCRSSP) and reverse polymerase chain reaction with sequence specific oligonucleotide probe (PCRSSOP) were used to type the HLADR alleles of 4229 blood samples in Xian population and their typing efficacy was compared. RESULTS: The antigens with highest frequency in Xian population were HLA DRB1*15, DRB1*09 and DRB1*12. Significant difference in antigen frequency was observed between different populations. For the same population, different typing methods were of various typing efficacy. CONCLUSION: PCRSSP reaction pattern excels reverse PCRSSOP in HLADR typing. ......

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