Highª²dose conventional fractionted and hypofractionted of threeª²dimensional conformal radiotherapy for primary nonª²small cell cancer

    DUAN Yongª²Jian, TANG Wenª²Chun, HAN Xiaoª²Li, QI Liª²Xia, WANG Zhiª²Wei

    epartment of Radiotherapy, First Hospital, Henan University, Kaifeng 475001, China

    ¡¾Abstract¡¿ AIM: To assess the responses and side effects of conventional fractionation (CF) regimen and hypo fractionation (HF) regimen in threeª²dimensional conformal radiotherapy (3DCRT) for primary nonª²small cell lung cancer. METHODS: Eightyª²seven patients with primary nonª²small cell lung cancer who were suitable for 3DCRT were randomly divided into two groups: 44 cases entered in the CF group and 43 cases in the HF group. The CF group received 5-7 Gy per day, 5 d per week, to a total dose of 36-60 Gy, the HF group were treated with the dose as that of the CF group, but once in two days. Those patients of central lung cancer and mediastinal lumph nodes lung cancer received conventional externalª²beam radiotherapy at the same time, with a total dose of 40-46 Gy. RESULTS: The local control rates at 1, 2 and 3 years were respectively 84.1%, 65.9% and 52.3% in the CF group and those in the HF group were respectively 79.1%, 51.2% and 27.9%. There were significant differences between the two groups (¦Ö2=4.64, P=0.035). The surgical rates at 1, 2 and 3 years were respectively 77.3%, 59.1% and 36.4% in the CF group and those in the HF group were 60.5%, 46.5% and 18.6%. The difference was significant (¦Ö2=4.30, P=0.041). The incidences of grade 1 and 2 acute esophagitis in the CF group were 20 cases and 16 cases in the HF group (¦Ö2=0.61, P=0.45). The incidences of grade 1 and 2 Radiotion Pneum onitis in the CF group were 10 cases and 7 cases in the HF group (¦Ö2=0.58, P=0.46). CONCLUSION: The CF regimen of 3DCRT is superior to the HF regimen of 3DCRT for primary nonª²small cell lung cancer. ......