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    Effects of cutting balloon angioplasty on serum levels of ILª²6 and CRP of UAP patients

    CHENG Kang£¬LI Weiª²Jie£¬JIA Guoª²Liang£¬WANG Haiª²Chang, LUAN Rongª²Hua, LI Qi, GUO Wenª²Yi, LU Anª²Lin, LI Chengª²Xiang, WANG Xiaoª²Yan

    Department of Cardiovasology, Xijing Hospital, Department of Immunology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To compare the effects of CBA on serum ILª²6 and CRP levels of unstable angina pectoris (UAP) patient with BA. METHODS: A total of 65 UAP patients were randomly divided into two groups, respectively, accepted CBA or BA , and stent were plant in all patients after balloon angioplasty. Coronary sinus blood was collected before angioplasty, immediate after as well as 2 h and 6 h after angioplasty to measure the content of ILª²6. Veins blood was collected before angioplasty, 6 h as well as 24 h and 48 h after angioplasty to measure the serum content of CRP. The serum levels of ILª²6 and CRP were all measured by ELESCA. RESULTS: There was no significant difference of the target lesions or the clinic characteristics between the two groups. The maximum balloon filling pressure and implant pressure of stent in group CBA was significantly lower than that in group BA (P<0.01) . The serum level of ILª²6 was significantly higher in group BA than that of CBA immediate after angioplasty, also keep raising at 2 h and 6 h (P<0.01) . The serum level of CRP was significantly higher in groupBA than that of group CBA at 6 h as well as 24 h and 48 h (P<0.01). CONCLUSION: The results suggest that CBA can significantly reduce the production of ILª²6 and CRP than that of BA. This may indicated that CBA and also plus stent implantation produce less vessel wall injury and, consequently, less inflammation stimulated, which may account for the lower rate of restenosis and cardiovascular events of CBA. ......