头孢克肟__(期刊论文)

头孢克肟胶囊在健康人体内的相对生物等效性

http://www.100md.com 《第四军医大学学报》 2003年第7期

头孢克肟,,头孢克肟；药代动力学；生物等效性；高效液相色谱法,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院药剂科, 陕西西安 710033)

    Relative bioequivalence and pharmacokinetics of Cefixime capsules in healthy volunteers

    ZHAO Lei, WEN AiDong, ZHANG SanQi, TONG LiPing, WU Yin

    Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To compare the pharmacokinetic parameters and relative bioavailability of domestic and imported Cefixime capsules in healthy volunteers and to study the quality of the medicine. METHODS: A single oral dose of 200mg domestic and imported Cefixime capsules was given to 12 healthy volunteers in a randomized twoperiod crossover study. The concentrations of Cefixime in serum were determined by HPLC method. The main pharmacokinetics parameters (AUC, ρmax and Tmax) were analyzed by two simultaneous onesided t test. RESULTS: The concentration time curves of domestic and imported Cefixime capsules conformed to the onecompartment open model with firstorder absorption. The AUC (0~24 h), ρmax and Tmax of domestic and imported Cefixime capsules were (25.88±3.75 )and ( 24.67±4.30)mg·h-1·L-1 ......

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