Effects of hyperoxic liquid on antioxidant level in experimental silicosis rabbits

    CHAI Wei, ZHANG Guiª²He, ZHANG Hui, WANG Shuang, GAO Changª²Jun, ZHAO Hongª²Xi

    1Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China, 2Department of Anesthesiology, Qindu College of Stomatology, 3Center of Electron Microscopy, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To explore the effects of hyperoxic liquid on the antioxidant level in experimental silicosis rabbits. METHODS: The silicosis rabbit model was prepared by nonª²exposure bronchus injection and rabbits were divided randomly into three groups : control group, silica group and hyperoxic liquid + silica group. After 12 weeks, the activity of SOD and GSHª²PX of silicosis rabbits and the concentrations of MDA in lungs and ACP, and LDH in BALF were determined. RESULTS: The activities of SOD and GSHª²PX significantly decreased in silica group, but the contents of ADP, LDH and MDA were significantly higher than those in the control group(P<0.05). Compared with those in silica group, the SOD and GSHª²PX activities of hyperoxic liquid + silica group were significantly higher, while the ADP, LDH and MDA contents of hyperoxic liquid + silica group were significantly lower, with significantly statistical difference (P<0.05). CONCLUSION: Hyperoxic liquid can enhance the antioxidant level in silicosis rabbits and partly restrain the development of silicosis. ......