鳖甲煎丸药理学研究.PDF
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Responses in Established Cardiac Pressure Overload Hypert rophy
in Rats with Aortic Banding [ J ] . J . Clin. Invest , 1995 , 96 :
276822774.
[ 4 ] Wei N G, Kaichiro K, Kenji Y, et al . α12Adrenoceptor agonists
and IGF21 , myocardial hypert ropic factors , regulate the Kv1. 5k
+ channel expression differentially in cultured newborn rat ven2
t ricular cells[J ] . Eur J Physiol ,1998 ,436 :26232.
[ 5 ] Nanette H B and Larry K. Adrenergic regulation of the skeletal2
actin gene promoter during myocardial cell hypert rophy [ J ] .
Proc. Natl . Acad. Sci ,1991 ,88 (pp) :213222136.
[ 6 ] Peter H S , Angela C. Cellular mechanisms of cardiac hypert rophy
[J ] . J Mol Med ,1998 ,76 :7252746.
[ 7 ] Howard E M , Kenneth M B. Cardiac Hypert rophy , Mechanical ,Neural , and Endocrine Dependence [ J ] . Circulation , 1991 , 83
(1) :13225.
[ 8 ] Kent R L , Hoober J K, Cooper G I V. Load responsiveness of
proein synthesis in adult mammalian myocardium: Role of cardiac
deformation linked to sodium influx[J ] . Circ Res , 1989 ,64 :742
85.
[ 9 ] Chua B H L , Russo L A , Gordon EE , et al . Faster ribosome syn2
thesis induced by elevated aortic pressure in rat heart [J ] . Am J
Physilol ,1987 ,252 :C3232C327.
[ 10 ] 王本祥.现代中药药理学[M] . 天津:天津科学技术出版社,1997. 117621177.
鳖甲煎丸药理学研究
曾凡波 , 晏菊姣 , 万 波 , 李风英
(华中科技大学同济医学院药学院 ,湖北 武汉 430030)
关键词:鳖甲煎丸 活血化瘀 软坚散结
摘要:目的:证实鳖甲煎丸是否具有活血化瘀 ,软坚散结功能。方法:应用血瘀、大鼠纤维化肝胶原蛋白和尿羟脯氨酸排
泄量、抗肿瘤等药理模型证实其功能。结果: (1) 本品具有促羊红细胞与自身血块的吸收作用。(2) 本品通过对肝硬变
的大鼠治疗后肝胶原纤维减少和胶原蛋白含量明显低于肝硬变组 ,同时能使肝硬变大鼠尿羟脯氨酸排泄量显著性增加 ,表明药物有促进胶原纤维降解的作用 ,使已形成的肝胶原重吸收。(3) 本品有明显的抑制 S180肿瘤生长作用。结论:本
品具有活血化瘀、软坚散结作用。
中图分类号:R285. 2 文献标识码:A 文章编号:100121528 (2002) 0720529203
Pharmacological study on Biejiajian Pills
ZEN G Fan2bo , YAN J u2jiao , WAN Bo , L I Feng2ying
( Col lege of Pharmacy , Tongji Medical Col lege , Huaz hong Universi ty of Science and Technology , Wuhan 430030 , Chi na)
Key words : Biejiajian Pill , promote blood circulation to remove blood stasis , sof ten the hard lumps and dispel the
nodes
Abstract : Objective : To confirm whether Biejiajian Pill has the action of promoting blood circulation to remove
blood stasis , sof tening the hard lumps and dispelling the nodes. Methods : The blood stasis model , anti2tumor
model , the model of collagen and urinary hydroxyproline evacuating f rom fibrous liver of rat and the other phar2
macological models were prepared to confirm the action of the pill . Results : (1) This pill has the absorption of
erythrocyte and blood clot of it self . (2) Af ter the pill being given to the rat s with cirrhosis , the hepatitisfibrils
decreased , the excretion of urinary hydroxyproline increased and the content of collagen of the therapeutics
group was less than the cont rol group. All of those suggested that this drug has the action of promoting the
degradation of the collagen fiber and reabsorption of the hepatitis collagen. (3) This pill can apparently inhibit
the proliferation of S180 . Conclusion : The drug has the action of promoting blood circulation to remove blood
stasis , sof tening the hard lumps and dispel the nodes.
收稿日期:2001207206
作者简介:曾凡波(1951~) ,男,副教授,硕士生导师。
925
2002年 7 月
第 24 卷 第 7 期
中 成 药
Chinese Traditional Patent Medicine
J uly , 2002
Vol . 24 No. 7
? 1995-2005 Tsinghua Tongfang Optical Disc Co., Ltd. All rights reserved. 鳖甲煎丸是东汉末年由张仲景所创 ,收载于《伤
寒杂病论》,处方由鳖甲胶、阿胶、蜂房(炒) 、鼠妇虫、蜣螂、柴胡、黄芩、半夏(制) 、党参、干姜、白芍等二十
三味药物组成 ......
in Rats with Aortic Banding [ J ] . J . Clin. Invest , 1995 , 96 :
276822774.
[ 4 ] Wei N G, Kaichiro K, Kenji Y, et al . α12Adrenoceptor agonists
and IGF21 , myocardial hypert ropic factors , regulate the Kv1. 5k
+ channel expression differentially in cultured newborn rat ven2
t ricular cells[J ] . Eur J Physiol ,1998 ,436 :26232.
[ 5 ] Nanette H B and Larry K. Adrenergic regulation of the skeletal2
actin gene promoter during myocardial cell hypert rophy [ J ] .
Proc. Natl . Acad. Sci ,1991 ,88 (pp) :213222136.
[ 6 ] Peter H S , Angela C. Cellular mechanisms of cardiac hypert rophy
[J ] . J Mol Med ,1998 ,76 :7252746.
[ 7 ] Howard E M , Kenneth M B. Cardiac Hypert rophy , Mechanical ,Neural , and Endocrine Dependence [ J ] . Circulation , 1991 , 83
(1) :13225.
[ 8 ] Kent R L , Hoober J K, Cooper G I V. Load responsiveness of
proein synthesis in adult mammalian myocardium: Role of cardiac
deformation linked to sodium influx[J ] . Circ Res , 1989 ,64 :742
85.
[ 9 ] Chua B H L , Russo L A , Gordon EE , et al . Faster ribosome syn2
thesis induced by elevated aortic pressure in rat heart [J ] . Am J
Physilol ,1987 ,252 :C3232C327.
[ 10 ] 王本祥.现代中药药理学[M] . 天津:天津科学技术出版社,1997. 117621177.
鳖甲煎丸药理学研究
曾凡波 , 晏菊姣 , 万 波 , 李风英
(华中科技大学同济医学院药学院 ,湖北 武汉 430030)
关键词:鳖甲煎丸 活血化瘀 软坚散结
摘要:目的:证实鳖甲煎丸是否具有活血化瘀 ,软坚散结功能。方法:应用血瘀、大鼠纤维化肝胶原蛋白和尿羟脯氨酸排
泄量、抗肿瘤等药理模型证实其功能。结果: (1) 本品具有促羊红细胞与自身血块的吸收作用。(2) 本品通过对肝硬变
的大鼠治疗后肝胶原纤维减少和胶原蛋白含量明显低于肝硬变组 ,同时能使肝硬变大鼠尿羟脯氨酸排泄量显著性增加 ,表明药物有促进胶原纤维降解的作用 ,使已形成的肝胶原重吸收。(3) 本品有明显的抑制 S180肿瘤生长作用。结论:本
品具有活血化瘀、软坚散结作用。
中图分类号:R285. 2 文献标识码:A 文章编号:100121528 (2002) 0720529203
Pharmacological study on Biejiajian Pills
ZEN G Fan2bo , YAN J u2jiao , WAN Bo , L I Feng2ying
( Col lege of Pharmacy , Tongji Medical Col lege , Huaz hong Universi ty of Science and Technology , Wuhan 430030 , Chi na)
Key words : Biejiajian Pill , promote blood circulation to remove blood stasis , sof ten the hard lumps and dispel the
nodes
Abstract : Objective : To confirm whether Biejiajian Pill has the action of promoting blood circulation to remove
blood stasis , sof tening the hard lumps and dispelling the nodes. Methods : The blood stasis model , anti2tumor
model , the model of collagen and urinary hydroxyproline evacuating f rom fibrous liver of rat and the other phar2
macological models were prepared to confirm the action of the pill . Results : (1) This pill has the absorption of
erythrocyte and blood clot of it self . (2) Af ter the pill being given to the rat s with cirrhosis , the hepatitisfibrils
decreased , the excretion of urinary hydroxyproline increased and the content of collagen of the therapeutics
group was less than the cont rol group. All of those suggested that this drug has the action of promoting the
degradation of the collagen fiber and reabsorption of the hepatitis collagen. (3) This pill can apparently inhibit
the proliferation of S180 . Conclusion : The drug has the action of promoting blood circulation to remove blood
stasis , sof tening the hard lumps and dispel the nodes.
收稿日期:2001207206
作者简介:曾凡波(1951~) ,男,副教授,硕士生导师。
925
2002年 7 月
第 24 卷 第 7 期
中 成 药
Chinese Traditional Patent Medicine
J uly , 2002
Vol . 24 No. 7
? 1995-2005 Tsinghua Tongfang Optical Disc Co., Ltd. All rights reserved. 鳖甲煎丸是东汉末年由张仲景所创 ,收载于《伤
寒杂病论》,处方由鳖甲胶、阿胶、蜂房(炒) 、鼠妇虫、蜣螂、柴胡、黄芩、半夏(制) 、党参、干姜、白芍等二十
三味药物组成 ......
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