作者简介:赵朝伟(1978 - ) ,男,正攻读硕士学位,主要从事药物新剂型及新药的开发研究。

    姜红止痛搽剂的质量标准

    赵朝伟1

    ,吴承云2

    ,吴纯洁1

    ,张朝燕1

    ,谢绍鹏1

    11成都中医药大学 ,四川 成都 610075 ;21四川省药品检验所 ,四川 成都 610031

    摘要: 目的 建立姜红止痛搽剂的质量标准。方法 采用薄层色谱法(TLC)对制剂中的姜黄、红花、乳香、没药进行定性鉴

    别;采用高效液相色谱法(HPLC) 测定制剂中姜黄素的含量。结果 TLC分离效果好 ,斑点清晰;姜黄素含量在 0. 07～0. 35μg

    范围内 ,线性关系良好( r = 0. 9993) ,平均回收率为99. 92 % , RSD = 1. 67 %( n = 5) 。结论 所用方法专属性强、重复性好 ,可用

    于该制剂的质量控制。

    关键词: 姜红止痛搽剂;姜黄素;TLC;HPLC

    中图分类号:R917 文献标识码:A 文章编号:1006 - 0103(2003) 04 - 0267 - 02

    The quality standards for Jianghong Zhitong liniment

    ZHAO Chao - wei

    1

    ,WU Cheng - yun2

    ,WU Chun - jie

    1

    ,ZHANG Chao - yan1

    ,XIE Shao - peng1

    1. Chengdu University of TCM , Chengdu 610075 , China ;2. Sichuan Provincial Institute for Drug Control , Chengdu 610031 , China

    Abstract :OBJECTIVE To establish the quality control standards for Jianghong Zhitong liniment .METHODS Rhizoma Curcumae longae ,Flos carthami , Olibanum , Myrrha were identified by TLC;The content of curcumin in Jianghong Zhitong was determined by HPLC.RESULTS

    The identified characteristics of chromatography were distinct and the spots were clear ; The linear relationship was good for curcumin

    (0. 07 - 0. 35μg) , r = 0. 9993. The average recovery was 99. 92 % ,RSD = 1. 67 %. CONCLUSION These methods are specific and accu 2

    rate. They can be used as the quality control method of this preparation.

    Key words : Jianghong Zhitong liniment ;Curcumin ;TLC;HPLC

    CLC number :R917 Document code :A Article ID :1006 - 0103(2003) 04 - 0267 - 02

    姜红止痛搽剂由姜黄、红花、乳香、没药等六味

    中药组成 ,具有活血化淤、通络止痛等功效 ,临床用

    于治疗软组织损伤、风湿关节痛、局部肿胀、淤斑等

    症。为了有效的控制产品质量 ,现采用薄层色谱法

    对姜黄、红花、乳香、没药进行定性鉴别 ,用高效液相

    色谱法测定姜红止痛搽剂中姜黄素的含量。

    1 实验部分

    111 仪器和材料

    LC0 - 10ATvp 高效液相色谱仪(日本岛津) ;SPD

    - 10Avp 紫外可见检测器(浙江大学 N2000 色谱工

    作站) ......