叶酸治疗萎缩性胃炎并改变P16蛋白表达
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刘丽华, 吴汉平, 张方信, 刘 斌, 董 亮,
萎缩性胃炎;叶酸;P16蛋白;甲基化,刘丽华,吴汉平,张方信,刘斌,董亮,钱震,通讯作者:,Effectoffolicacidonatrophicgastr
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刘丽华, 吴汉平, 张方信, 中国人民解放军兰州军区兰州总医院消化科 甘肃省兰州市 730050
刘斌, 董亮, 钱震, 中国人民解放军兰州军区兰州总医院病理科 甘肃省兰州市 730050
甘肃省中青年科学技术基金资助项目, No. YS031-A21-023
通讯作者: 刘丽华, 730050, 甘肃省兰州市小西湖西街98号, 兰州军区兰州总医院消化科. LLH487726@163.com
收稿日期: 2005-09-28 接受日期: 2005-09-30
Effect of folic acid on atrophic gastritis and expression of P16 protein
Li-Hua Liu, Han-Ping Wu, Fang-Xin Zhang, Bin Liu, Liang Dong, Zhen Qian
Li-Hua Liu, Han-Ping Wu, Fang-Xin Zhang, Department of Gastroenterology, General Hospital of Chinese PLA, Lanzhou 730050, Gansu Province, China
Bin Liu, Liang Dong, Zhen Qian, Department of Pathology, General Hospital of Chinese PLA, Lanzhou 730050, Gansu Province, China
Supported by the Science and Technology Foundation for Young and Middle-Aged People of Gansu Province, No. YS031-A21-023
Correspondence to: Li-Hua Liu, Department of Gastroenterology, General Hospital of Chinese PLA, 98 Xiaoxihu West Street, Lanzhou 730050, Gansu Province, China. LLH487726@163.com
Received: 2005-09-28 Accepted: 2005-09-30
Abstract
AIM: To study the mucosal changes, P16 protein expression and p16 gene methylation status in atrophic gastritis after treatment of folic acid (FA).
METHODS: Fifty-six patients, who were diagnosed with gastroendoscopy and pathological examination, were randomly assigned into FA and non-FA treatment group (control). Before and after treatment, the clinical symptoms of the patients, the levels of plasma FA, and the expression of P16 protein were observed. Meanwhile, the methylation status of p16 gene was detected by methylation specific polymerase chain reaction (MSP).
RESULTS: After treatment with FA, The clinical symptoms of patients alleviated rapidly and lasted a longer period in FA group. Meanwhile, the level of plasma FA was significantly increased (47.98 ± 2.68 µg/L vs 14.37 ± 3.56 µg/L, P < 0 ......
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