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槟榔碱促结肠平滑肌细胞收缩及对胞内钙离子浓度的影响
http://www.100md.com 梁宁霞, 衣兰娟, 田 琳, 胡 凡, 刘翠萍,
结肠;平滑肌细胞;细胞培养;槟榔碱;钙离子;激光共聚焦显微镜,梁宁霞,衣兰娟,田琳,魏睦新,刘翠萍,胡凡,梁宁霞,EffectsofArec
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     梁宁霞, 衣兰娟, 田琳, 魏睦新, 南京医科大学第一附属医院中医科 江苏省南京市 210029

    刘翠萍, 南京医科大学第一附属医院内分泌科 江苏省南京市 210029

    胡凡, 南京医科大学 江苏省南京市 210029

    梁宁霞, 2005年南京医科大学硕士, 讲师, 主要从事胃肠动力方面研究.

    江苏省科技厅国际合作项目, No. BZ2002066

    江苏省“135”工程重点人才项目, No. RC2002049

    通讯作者: 魏睦新, 210029, 江苏省南京广州路300号, 南京医科大学第一附属医院中医科.

    收稿日期: 2005-12-24 接受日期: 2006-02-11

    Effects of Arecolinehydrobromide on contraction and intracellular free Ca2+ concentrations of colonic smooth muscle cells

    Ning-Xia Liang, Lan-Juan Yi, Lin Tian, Fan Hu, Cui-Ping Liu, Mu-Xin Wei

    Ning-Xia Liang, Lan-Juan Yi, Lin Tian, Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

    Cui-Ping Liu, Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China

    Fan Hu, Nanjing Medical University, NanJing 210029, Jiangsu Province, China

    Supported by International Cooperation Projects from Science and Technology Department of Jiangsu Province, No. BZ2002066, and 135 Medical Emphasis grant from Government of Jiangsu Province, No. RC2002049

    Correspondence to: Dr. Mu-Xin Wei, Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 GuangZhou Road, Nanjing 210029, Jiangsu Province, China

    Received: 2005-12-24 Accepted: 2006-02-11

    Abstract

    AIM: To explore the possible role of Arecolinehy-drobromide (Ah) in the dynamics of digestive tract and the effects of Ah on the contraction of colon smooth muscle cells (SMCs) and the con-centration of intracellular [Ca2+]i.

    METHODS: SMCs from colon of mice were cultured in vitro. Based on different treatment methods, four groups were divided into as follows: Ah group in which cultured SMCs were stimulated by Ah; control group in which there was no additional treatment on cultured SMCs; Acetylcholine (Ach) group in which cultured SMCs were stimulated by Ach; Atropine group in which cultured SMCs were pretreated with atropine before Ah was added ......

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