胃癌组织Maspin, uPA, MMP-7表达的意义
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邓 玮, 易永芬, 刘丹丹
胃癌;Maspin;尿激酶型纤溶酶原激活物;基质金属蛋白酶-7,胃癌组织Maspin,uPA,MMP-7表达的意义,邓玮,易永芬,刘丹丹,邓玮,通讯作者:,SignificanceofMaspin
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邓玮, 易永芬, 刘丹丹, 重庆医科大学病理教研室 重庆市 400016
邓玮, 2003年重庆医科大学硕士生, 主要从事消化系统肿瘤的研究.
重庆市教委资助项目, No.040310
通讯作者: 易永芬, 400016, 重庆市医学院路1号, 重庆医科大学病理科. yiyongfen1953@yahoo.com.cn
电话: 023-68485789
收稿日期: 2005-12-31 接受日期: 2006-01-26
Significance of Maspin, uPA and MMP-7 expression in human gastric carcinoma
Wei Deng, Yong-Fen Yi, Dan-Dan Liu
Wei Deng, Yong-Fen Yi, Dan-Dan Liu, Department of Pathology, Chongqing Medical University, Chongqing 400016, China
Supported by the Fund from Chongqing Education Committee, No. 040310
Correspondence to: Yong-Fen Yi, Department of Pathology, Chongqing Medical University, Chongqing 400016, China. Yiyongfen1953@yahoo.com.cn
Received: 2005-12-31 Accepted: 2006-01-26
Abstract
AIM: To investigate the expression of Maspin, urokinase-type plasrninogen activator (uPA) uPA and Matrix metalloproteinase-7 (MMP-7) and their roles in the tumorigenesis and progre-ssion of gastric cancer.
METHODS: Immunohistochemistry SP method was used to detect the expression of Maspin, uPA and MMP-7 in tissues from gastric adenocarcinoma (n = 30), signet-ring cell carcinoma (n = 30), and normal gastric mucosa (n = 20).
RESULTS: The positive rates of Maspin, uPA and MMP-7 were 50%, 70% and 80%, respectively, in gastric adenocarcinoma, and they were 46.7%, 76.7% and 90%, respectively, in signet-ring cell carcinoma. However, the positive rates of Maspin, uPA, and MMP-7 were 90%, 35%, and 30%, respectively, in normal gastric mucosa. Maspin, uPA, and MMP-7 expression were significantly different between tissues from carcinoma and normal mucosa (P < 0.05 or P < 0.01). Maspin expression was significantly related to the depth of invasion and lymph node metastasis, but not to tumor size and TNM staging. The expression of uPA and MMP-7 were markedly related to the depth of invasion, lymph node metastasis and TNM staging, but not to tumor size ......
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