关键词: 介入性热疗;肝功;肾功;肝肿瘤;荷瘤兔

    摘 要:目的 研究经肝动脉介入热疗对荷瘤兔肝肾功能及生命体征的影响，探讨介入热疗治疗肿瘤的安全性. 方法 建立可供实验研究的兔VX2 移植性肝癌模型10只;30min内经兔肝动脉缓慢匀速注入60℃生理盐水40mL.分别于灌注前及灌注后1，3，5和7d检查肝、肾功的动态变化情况. 结果 荷瘤兔的呼吸、心率、体温都有一定程度的改变，但1h内均可恢复正常;ALT，AST于灌注后开始升高(ALT7倍，AST2倍)，之后逐渐恢复，1wk后恢复正常;胆红素、白蛋白及γ-GT无明显变化.对肾功指标的监测表明，热疗对肾脏无明显影响. 结论 介入性热疗对荷瘤兔生命体征及肝肾功的影响是轻度的、可逆的，可以耐受.

    How interventional thermotherapy via hepatic artery affects liver and kidney function in VX2 tumor┐bear┐ing rabbits

    CAO Xiao-Ming，WANG Zhi-Min，ZHANG Hong-Xin，CAO Wei，GUO Wei-Ping，WANG Yi-Qing，LI Wen-Xian，NI Dai-Hui，GUAN Yan

    Department of Interventional Radiology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:interventional thermo-therapy;liver function;re-nal function;liver-neoplasms;tumor-bearing rabbits

    Abstract:AIM To evaluate the injury of interventional thermo-therapy on tumor-bearing rabbit hepatic and renal tis-sues at60℃via hepatic artery.METHODS VX2 carcinoma cells were inoculated into the hepatic parenchyma of white rabbits.Forty mL saline at60℃was perfused via hepatic artery in30min ......