Metaª²analysis of risk factors of esophageal cancer in Xi¡¯an

    WANG Bo, ZHANG Yan, XU Deª²Zhong, ZHANG Lei, WANG Anª²Hui, SUN Changª²Sheng, LI Liangª²Shou

    1Department of Epidemiology, School of Preventive Medicine, Fourth Military Medical University, Xi¡¯an 710033£¬China, 2Department of Blood Type, Shaanxi Blood Center, Xi¡¯an 710061, China

    ¡¾Abstract¡¿ AIM: To investigate the risk factors of esophageal cancer (EC) in Xi¡¯an. METHODS: We reviewed data of caseª²control studies on risk factors of EC in Xi¡¯an and performed a metaª²analysis. RESULTS: Five caseª²control studies were chosen for our detailed review, and 840 EC cases and 1084 controls were analyzed in the five studies about EC in Xi¡¯an. Our metaª²analysis of risk factors for EC showed that significant factors of EC were tobacco smoking (male), alcohol drinking, intake of pickled vegetables, intake of fresh vegetables and family history of EC. The pooled OR values were 2.63(2.01-3.43), 1.74(1.21-2.51), 1.27(1.03-1.56), 0.46(0.35-0.61) and 3.75 (2.30-6.11) respectively (P<0.05). Doseª²effect analysis of tobacco smoking showed that the pooled OR for smoking dosage<20 per day and ¡Ý20 per day was 2.21 and 2.54 ......