轮状病毒_____轮状病毒;_肠炎;

轮状病毒性肠炎患儿血清和大便细胞因子的变化

http://www.100md.com 《第四军医大学学报》 2004年第21期

轮状病毒,,轮状病毒;,肠炎;,白细胞介素8;,肿瘤坏死因子α,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Alterations of serum and stool cytokine levels in children with rotavirus enteritis

    WANG YaQiang, MA XiaoJian, ZHANG Tao, ZHANG Tao

    1Department of Clinical Laboratory, 2Department of Pediatrics, Huaihe Hospital, Henan University, Kaifeng 475000, China, 3Department of Clinical Laboratory, First Hospital, Henan University of Science and Technology, Luoyang 471000, China

    【Abstract】 AIM: To explore the roles of cytokine interleukin8 (IL8) and tumor necrosis factorα (TNFα) in the pathogenesis of rotavirus (RV) enteritis and their clinical significance. METHODS: The levels of IL8 and TNFα in the serum and stool of 46 children with RV enteritis were detected by the doubleantibody sandwich ELISA technique. RESULTS: The levels of IL8 and TNFα in the serum and stool of children with RV enteritis at the acute phase were significantly higher than those in control group (P<0.01), and though they decreased rapidly at the convalescent stage (P<0.01), they were still higher than those in control group (P<0.01). CONCLUSION: IL8 and TNFα are involved in the pathogenesis of RV enteritis. ......

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