关键词: 前列腺增生/外科学;手术;创伤和损伤;白细胞介素-6;C-反应蛋白

    摘 要:目的 探讨前列腺增生(BPH)的3种外科治疗方法血清IL--6和CRP水平的变化. 方法 用前瞻、对比的临床实验，对117例分别进行开放性手术(OP)、经尿道气化电切术(TUEVAP)和组织间激光消融(ILC)的BPH患者，用酶联免疫吸附法(ELISA)检测其手术前后血清白细胞介素-6(IL-6)和C-反应蛋白(CRP)水平. 结果 3组患者血清IL-6和CRP水平术前无显著差异，但术后24h明显高于术前(P<0.05)，其中以开放手术组最高，TUEVAP组次之，ILC组最低;术后24h血清IL-6水平与手术时间、术中出血量明显相关(r=0.69，P=0.0000)，术后48h血清CRP水平与手术时间相关(r=0.83，P=0.0000). 结论 3种外科治疗方法中，开放性手术对机体的创伤最为严重，急性时相反应最大，经尿道气化电切术次之，组织间激光消融则最小.手术的操作时间和术中出血量是影响机体创伤程度的主要因素.

    Changes of the levels of Interleukin┐6and C┐reac┐tive protein following three surgical methods for BPH

    ZHONG Lin，WANG He，ZHANG Bo，WU Guo-Jun，CHEN Bao-Qi，QIN Rong-Liang，TANG Quen-Hui，YUAN Jian-Lin，WANG Peng-Fei

    Department of Urology Surgery，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:prostatic hyperplasia/surgery;wounds and in-juries;interleukin-6;C-reactive protein

    Abstract:AIM To study the trauma degree of the patients undergoing open prostatectomy(OPEN)，transurethral elec-trovaporisation-albation prostatectomy(TUEVAP)or inter-stitial laser coagulation(ILC).METHODS One hundred and seventeen patients underwent surgical treatment:OPEN(n=61) ......