关键词: 次声;大脑皮层;超微结构;脑损伤;大鼠

    摘 要:目的 探讨次声作用后鼠大脑皮层超微结构的变化及意义. 方法 将35只Ⅱ级雄性SD大鼠随机分为对照组和次声作用7，14，21和28d组5组，于8Hz，130dB次声环境下，每日暴露1次，每次2h;取大脑皮层用戊二醛和锇酸固定，透射电镜下观察脑超微结构的变化. 结果 次声作用后脑损伤以变性改变为主，可见于细胞内外的各种结构;早期随作用时间延长损伤逐渐加重，后期损伤有一定的恢复. 结论 次声可非特异性地损伤脑的超微结构;在相同的频率和声压级水平下，次声的损伤作用与次声的作用时间并非呈线性关系;脑组织对次声的损伤作用存在着一定的适应现象.

    Changes of pallium ultrastructure after infrasound damage in rats

    YE Lin GONG Shu-Ming HUANG Xiao-Feng WANG Feng LIU Jing CHEN Jing-Zao

    1 Department of Nutrition and Food Hygiene，Facul-ty of Preventive Medicine，

    2 Laboratory Center Elec-tronic Microscope，Faculty of Preclinical Medicine，

    3 Department of Physiotherapy and Rehabilitation，Xijing Hospital，Fourth Military Medical Universi-ty，Xi'an710033，China

    Keywards:infrasound;pallium;cerebral ultrastructure;brain injury;rats

    Abstract:AIM To study the changes and significance of cerebral ultrastructure after infrasound acts on the rats so as to probe into the mechanism of infrasound biologic effects.

    METHODS Thirty-five gradeⅡmale SD rats were random-ly divided into5groups:control group ......