Clinical significance of determination of soluble selectins and matrix metalloproteinasesª²9 in patients after successful cardiopulmonary resuscitation

    ZHANG Liª²Ping, LI Peiª²Jie, QIN Jing, CAO Wen, YAO Wei

    Second Affilated Hospital of Lanzhou Medical College, Lanzhou Emergency Center of Gansu Province, Lanzhou 730030, China

    ¡¾Abstract¡¿ AIM: To investigate whether patients after successful cardiopulmonary resuscitation (CPR) have elevated levels of soluble Pª²selectin (sPª²selectin) and matrix metalloproteinasesª²9 (MMPª²9) and to evaluate their clinical significance. METHODS: Plasma levels of sPª²selectin and MMPª²9 in 82 patients who survived ¡Ý48 h after CPR were determined on the second day after successful CPR. They were classified into different groups by whether they developed systemic inflammatory response syndrome (SIRS) or sepsis. Sixtyª²five nonª²critically ill patients served as control group. RESULTS: The incidence of SIRS was 68% after successful CPR. The plasma level of sPª²selectin was higher in patients with SIRS than those without SIRS or the control group (P<0.01). The plasma level of MMPª²9 was not significantly different between patients with SIRS and those without SIRS (P>0.05), but it was higher in both patient groups than that in the control group (P<0.01). 44% of the patients developed sepsis within 1 wk after CPR and the plasma level of sPª²selectin was higher in patients developing sepsis than those without sepsis (P<0.01), but the plasma level of MMPª²9 was not significantly different between the two groups (P>0.05). The plasma level of MMPª²9 was higher in the dead patients than that in survivors (P<0.01), but the plasma level of sPª²selectin was not significantly different between the two groups (P>0.05). CONCLUSION: SIRS is a frequent but unspecific response after CPR and it has no significant influence on the prognosis. Early determination of sPª²selectin and MMPª²9 after CPR may help to identify patients with a high risk for sepsis or a bad prognosis. ......