内皮细胞__(期刊论文)

U50,488H对大鼠肾动脉的舒张作用及其机制

http://www.100md.com 《第四军医大学学报》 2004年第23期

内皮细胞,,选择性κ阿片受体激动剂；肾动脉；阿片受体；内皮细胞；KATP通道,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Relaxant effect of U50,488H on renal artery in rats and its underlying mechanism

    HUAI Yong，WANG YueMin，MA Heng，SUN Xin，BI Hui，ZHANG Peng，PEI JianMing

    Department of Physiology，School of Basic Medicine，Fouth Military Medical University，Xi’an 710033，China

    【Abstract】 AIM: To investigate the relaxant effect of U50,488H (a selective κopioid receptor agonist) on renal artery in rats and the underlying mechanism. METHODS: Isolated renal artery was perfused and the tension of the vessel was measured. RESULTS: U50,488H had the significant dosedependent relaxant effect on rat renal artery. The relaxation of U50,488H on rat renal artery was enhanced with denuded endothelium. The relaxant effect of U50,488H on renal artery was not influenced in the presence of different blockers such as glibenclamide, LNAME, indomethacin, atropine, and propranalol. CONCLUSION: It is demonstrated for the first time that U50,488H significantly relaxes the renal artery of rats, which is attenuated by endothelium intact and bears no relationship to KATP channel, nitric oxide (NO), prostaglandin, muscarinicreceptor and βadrenoceptor. ......

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