肾小球肾炎__(期刊论文)

内源性哇巴因在肾小球疾病伴高血压及肾功能减退时的变化

http://www.100md.com 《第四军医大学学报》 2004年第23期

肾小球肾炎,,内源性哇巴因；肾小球肾炎；高血压；肾功能；β2微球蛋白,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Variance of endogenous ouabain in glomerulonephropathy with hypertension and renal hypofunction

    YIN AiPing，L ZhuoRen, JIANG HongLi，GUO YaJuan

    Department of Nephrology，First Hospital, Xi’an Jiaotong University， Xi’an 710061，China

    【Abstract】 AIM: To study the variance of endogenous ouabain (EO) in glomerulonephropathy with hypertension and renal hypofunction. METHODS: The serum EO of normal controls and patients with glomerulonephropathy accompanied with hypertension and renal hypofunction was detected with a method of ELISA coating, to find the relationship between the EO concentration and renal hypofunction. RESULTS: Patients with glomerular diseases had an increased serum EO concentration, which was not related to blood pressure (P<0.01). The EO levels (μg/L) in group of normal renal function (1.46±0.54)，azotemia (2.74±0.63) and uremia (3.58±0.79)，were all higher than that of normal controls (0.87±0.35) (P<0.01). A positive correlation was found between the degree of renal disfunction and serum EO concentration. Serum EO concentration changed earlier than serum and urineβ2MG. CONCLUSION: The level of EO increases obviously in glomerulonephritis especially with hypertension and renal hypofunction. Serum EO is more sensitive than blood and urine β2MG in detection of renal dysfunction. ......

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