关键词: 瘦素;外周血;卵泡液;生殖激素

    摘 要:目的 观察促排卵周期中瘦素的变化，探讨瘦素与卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2 )、孕酮(P)、睾酮(T)之间的关系. 方法 采集21个促排卵周期不同阶段的外周血，直径大于14mm卵泡的卵泡液;以正常月经周期为对照组，采集排卵前外周血.用ELISA法测定其瘦素水平，RIA法测定其生殖激素水平. 结果 促排卵周期中穿卵前外周血瘦素水平极显著高于应用GnRH-a卵巢功能被最大抑制时的瘦素水平(P<0.01).促排卵周期穿卵前外周血瘦素水平高于正常月经周期排卵前瘦素水平(P<0.05).卵泡液瘦素与同步外周血瘦素呈正相关(r=0.947，P<0.05).促排卵周期中卵泡液瘦素与卵泡液LH呈负相关(r=-0.604，P<0.05).卵泡液瘦素与卵泡液T呈正相关(r=0.634，P<0.05).外周血瘦素与外周血FSH，LH，PRL，E2 ，P无相关性(P>0.05).外周血瘦素与外周血T呈正相关(r=0.789，P<0.05). 结论 卵巢中瘦素来源于外周血;瘦素与生殖激素之间存在相互影响，可能参与生殖功能的调节.

    Correlation between leptin and other reproductive hormones during cycle of controlled hyperstimu┐lation

    ZOU Yu-Liang，LU Shu-Lan，CAO Zuan-Sun，CHEN Xiao-Yan，MAO Wen-Jun，QIU Shu-Dong Department of Obstetrics and Gynecology，First Medical University of Xi'an Jiaotong University，Xi'an710061，China

    Keywords:letpin;follicular fluid;peripheral blood;repro-ductive hormones

    Abstract:AIM To observe the change of leptin in the con-trolled Hyperstimulation and to study the correlation between the leptin levels and other reproductive hormones，FSH，LH，PRL，E2 ，P and T.METHODS We collected peripher-al blood samples in different periods of21cycles of the con-trolled hyperstimulation and the follicular fluid from follicle with diameter>14mm.Normal menstrual cycle was taken as a control group and circulation blood was collected in the pe-riod near ovulation.The leptin was detected by means of ELISA.Other reproductive hormones were detected by RIA.RESULTS The blood leptin level of the patients under cycle of the controlled hyperstimulation treatment before their fol-licular puncture was obviously higher than that when the function of their ovaries was restricted to the greatest degree by using GnRH-a to the patients(P<0.01).The blood lep-tin level of the patients under cycle of the controlled hyper-stimulation treatment before their follicular puncture was higher than that in the normal menstrual cycle(P<0.05).There was a positive correlation between leptin concentration and peripheral blood(r=0.947 ......