(山东省枣庄市卫生学校， 山东 枣庄 277101)

    摘 要：目的：探讨通心络胶囊对冠脉内支架置入术后患者体内凝血—纤溶系统和血管紧张素Ⅱ的影响及其作用机制。方法：58例冠脉内支架置入术后患者随机分为两组:分别用常规药物(对照组29例)和常规药物加通心络胶囊(治疗组29例)治疗，观察对术后患者凝血—纤溶相关指标：组织型纤溶酶原激活物(t-PA)、纤溶酶原活化剂抑制物1(PAI-1)、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白原(FIB) 和血管紧张素Ⅱ的影响。结果：①治疗15d后，治疗组血管紧张素Ⅱ与对照组比较，差异无显著性(P>0.05)。②治疗60天后，治疗组AT-Ⅲ、t-PA较对照组显著升高(P<0.01)，PAI-1治疗组低于对照组(P<0.05)，FIB治疗组显著低于对照组(P<0.01)。结论：通心络胶囊通过提高体内AT-Ⅲ、t-PA水平，降低FIB、PAI-1和血管紧张素Ⅱ水平来调节体内凝血—纤溶系统平衡。

    关键词： 冠心病； 支架置入术； 通心络胶囊； 凝血纤溶； 血管紧张素Ⅱ

    Effect of Tongxinluo Capsule on Coagulant and Fibrinolysis System and Angiotension-Ⅱ in Patients with CHD after Intracoronary Stenting

    ZHANG Wei

    (Zaozhuang Health School， Shandong Zaozhuang 277101, China)

    Abstract: Objective: To explore the effect and mechanism of Tongxinluo capsule on coagulant and fibrinolysis system and angiotensionⅡin patients with coronary heart disease after intracoronary stenting. Methods: Fifty-six patients ,accepted intracoronary stenting ,were randomly into 2 groups ,the contro1 group treated with conventional medicine and the treated group treated with conventional medicine plus tongxinluo capsule .The changes of coagulant-fibrinolysis related indexes ,including t-PA,PAI-1,AT-Ⅲ ......