大鼠灌胃给芩栀胶囊的长期毒性实验研究
芩栀胶囊,,芩栀胶囊；,长期毒性；,血液学指标；,脏器系数,1材料,2方法和结果[1，2],3讨论,参考文献：
摘要：目的：观察芩栀胶囊对大鼠有无长期毒性作用。方法：芩栀胶囊以8.0，16.0，32.0 g(生药)/kg剂量(分别相当于临床成人日用剂量的20，40，80倍)，连续给大鼠灌胃给药28 d，停药14 d,分别称量动物体重，计算脏器系数，测定血液学和血液生化学指标，并作病理组织学检查。结果：芩栀胶囊各剂量组动物的一般状况、体重、摄食量、主要脏器系数、血液学指标及血液生化学指标，与正常对照组比较，均未见明显差异；病理检查未见与药物毒性相关的主要脏器组织形态学改变；停药后也未见药物延迟性毒性反应。结论：芩栀胶囊长期用药无明显毒性，推测临床拟用剂量是安全的。关键词： 芩栀胶囊； 长期毒性； 血液学指标； 脏器系数
The Rat Chronic Toxicity Test of Qinzhi Capsule Taken Orally
YAO Gan，HE Zongyu，FANG Taihui
(1.College of Bioinformation of Chongqing University of Posts and Telecommunications,Chongqing 400065,China;2.Nanjing University of TCM, Nanjing 210029,China)
Abstract：Objective:To observe the rat chronic toxicity induced by Qinzhi capsule taken orally. Methods:The rats were orally given Qinzhi capsule for 28 days with the doses of 8.0,16.0 and 32.0g(crude medicinal materials)/kg(20,40 and 80 times of clinic dose) and for 14 days of stopping administration. The rat’s weights, organ coefficients, the indexes of hematology and biochemistry were determined, and the pathological examination were carried out. Results:The outer appearance and behavior, weights, organ coefficient, the indexes of hematology and biochemistry in rats had no significant difference by comparing with control group. The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration. Conclusion:Qinzhi capsule has no significant toxicity for long-term administration on rats. It infers that the drawing up doses in clinic will be safe. ......
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