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瘦素对大鼠血管平滑肌舒缩功能的影响及其机制

http://www.100md.com 《第四军医大学学报》 2004年第20期

主动脉,,瘦素；主动脉，胸；Na+K+交换ATP酶；PI3K；钙,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effects of leptin on contraction and relaxation of vascular smooth muscle in rats and its mechanism

    HU Zhi, MA AiQun, GENG Tao

    Department of Cardiovasology, First Hospital, Xian Jiaotong University, Xian 710061, China

    【Abstract】 AIM: To investigate the effects of leptin on the contraction and relaxation of isolated thoracic aortic smooth muscle and its mechanism. METHODS: Isolated thoracic aorta was perfused and the tension of the vessel was measured. The activity of Na+K+ATPase of vascular smooth muscle cells (VSMC) was measured by biochemical method. RESULTS: ① Leptin promoted the vasoconstriction induced by noradrenaline and prolonged the relaxation duration of isolated thoracic aorta. ② Leptin inhibited the activity of Na+K+ATPase. ③ Wortmannin inhibited the above effects of leptin on VSMC. CONCLUSION: ① The effect of leptin on contraction and relaxation of isolated vascular smooth muscle may be related to the intracellular change of the activity of Na+K+ATPase. ② Leptin affects the activity of Na+K+ATPase by intracellular PI3K signal pathway. ......

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