当前位置: 首页 > 期刊 > 《第四军医大学学报》 > 2004年第20期
编号:10929069
受损背根节神经元持续性钠流的检测
http://www.100md.com 《第四军医大学学报》 2004年第20期
持续性钠流,,神经节,脊;膜片钳术;持续性钠流;阈下膜电位振荡,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Detection of persistent sodium current in injured DRG neurons

    LIU ZhiYang, WANG YuYing, WANG WenTing, HU SanJue

    PLA Institute of Neuroscience, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To detect persistent sodium current and to study its relationship with subthreshold membrane potential oscillation in injured DRG neurons. METHODS: Wholecell patchclamp experiments were performed with medium and small DRG neurons freshly isolated from rats. RESULTS: In the voltageclamp, DRG neurons with depolarizated membrane potential from -80 mV to -30 mV in ramp, produced a persistent sodium current for 150200 ms. The current with amplitude of 89200 pA was sensitive to 100 nmol/L TTX. In the currentclamp, when 100 nmol/L TTX was added to the cells with subthreshold membranepotential oscillation (SMPO), the oscillation disappeared. CONCLUSION: The INap detected in the injured DRG neurons may be in some way responsible for the production of SMPO. ......

您现在查看是摘要页,全文长 8460 字符