【摘要】 目的 探讨不同阶段慢性肾炎患者血浆一氧化氮(NO)和内皮素(ET)水平变化及其临床意义。方法 分别采用硝酸还原法和放射免疫分析法对慢性肾炎肾功不全代偿期(CRFEP)组(n=26)、慢性肾炎肾功不全失代偿期(CRFLP)组(n=23)及对照组(n=25)血浆NO和ET的含量同时进行测定。结果 CRFEP、CRFLP患者血浆NO水平均低于对照组(P均<0.01)，且CRFLP组明显低于CRFEP组(P<0.01)；CRFLP组、CRFEP组患者血浆ET水平高于对照组(P<0.01)，且CRFLP组明显高于CRFEP组(P<0.01)。结论 血浆NO和ET代谢失调导致肾动脉与肾内动脉痉挛和血栓形成，二者共同参与了慢性肾炎的发生、发展。

    【关键词】 慢性肾炎； 一氧化氮； 内皮素

    Clinical study on changes of plasma nitric oxide (NO) and endothelin (ET) in patients with chronic glomerulonephritis

    ZHAO Ya-hong，YANG Zhao-hui.

    The General Hospital of Tianfu Coal Bureau，Chongqing 400704，China

    【Abstract】 Objective The significances of plasma nitric oxide (NO) and endothelin (ET) concentrations in chronic glomerulonephritis of different stage were studied. Methods Plasma levels of NO and ET were measured simultaneously in 26 patients with chronic renal failure the earlier period (CRFEP) of chronic glomerulonephritis ......