Association between DRD3 gene Ser9Gly polymorphism and schizophrenia in center families

    L¦a Luª²Xian, ZHANG Hongª²Xing, GUO Suª²Qin, SHI Yuª²Zhong

    1Institute of Biomedical Engineering, Central South University, Changsha 410008, China, 2Mental Health Institute, Xiangya Medical School, Central South University, Changsha 410011, China, 3Department of Psychiatry, Second Affilicated Hospital, Xinxiang Medical College, Xinxiang 453002, China

    ¡¾Abstract¡¿ AIM: To investigate the association between the dopamine receptor D3(DRD3) gene Ser9Gly polymorphism located in the first exon and the susceptibility of schizophrenia. METHODS: The genotypes were determined by restriction fragment length polymorphism (RFLP) analysis for the above polymorphism in 124 schizophrenic hospitalized patients from October 2001 to December 2003 in our hospital and their parents. The correlation between the polymorphism of the gene and schizophrenia was investigated by transmission disequilibrium test (TDT) and haplotype relative risk test (HRR). The data were analyzed with software SPSS 11.5. RESULTS: One hundred and one out of the 124 families were examined with TDT and HRR. Disequilibrium existed in the whole samples and the male families, but did not exist in the female families. Between the 2 groups with or without the family history, no significant difference in disequilibrium was found by TDT. But with HRR, significant disequilibrium existed in the group with positive family history, while no disequilibrium was found in the other group. CONCLUSION: There is a correlation between the DRD3 gene Ser9Gly polymorphism and schizophrenia, especially for male schizophrenia. No obvious evidence shows the different disequilibrium in the groups classified by different family history. ......