前列腺癌_____前列腺癌；γ射线；基质金属蛋白酶类

60Co γ射线辐照对人前列腺癌PC3细胞MMP家族基因表达的影响

http://www.100md.com 《第四军医大学学报》 2005年第22期

前列腺癌,,前列腺癌；γ射线；基质金属蛋白酶类,60Coγ射线辐照对人前列腺癌PC3细胞MMP家族基因表达的影响,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of 60Co γray external irradiation on MMP expression in human PC3 prostate cancer cell line

    ZHANG XiaoYi, HONG BaoFa, ZHOU JianGuang, ZOU Lian, ZHOU LiQuan

    1Department of Urology, Second Artillery General Hospital of PLA, Beijing 100088, China, 2Department of Urology, PLA General Hospital, Beijing 100853, China, 3Institute of Bioengineering, Academy of Military Medical Sciences, Beijing 100853, China

    【Abstract】 AIM: To investigate the changes of the invasive potential induced by 60Co γray external irradiation of human PC3 prostatic cancer cell. METHODS: The cultured PC3 cell proliferation was performed using MTT and the clony formation was measured in soft agar, and the expressions of MMP2 and MMP9 (matrix metalloproteinases2 and matrix metalloproteinases9) were performed using WesternBlot before and after irradiation with 1Gy, 3Gy, 5Gy dose 60Co γray. RESULTS: ① PC3 cell proliferation was significantly inhibited by 60Co γray external irradiation at the dose of 1Gy, 3Gy and 5Gy. ② PC3 cell clony ratio decreased following the increasing dose of 60Co γray. ③ Western Blot showed MMP9 overexpression after irradiation with the 60Co γray, but MMP2 showed a downtrend. CONCLUSION: The overexprssion of MMP9 in PC3 cells suggests that the ability of survival prostatic carcinoma cells migration and invasiveness is enhanced by the sublethal irradiation. ......

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