肾移植_____肾移植；肾病；转移生长因子β

肾移植后早期检测尿转化生长因子β的临床意义

http://www.100md.com 《第四军医大学学报》 2005年第19期

肾移植,,肾移植；肾病；转移生长因子β,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Clinical significance of urine TGFβ1 in predicting longterm renal allograft function

    WANG PingXian, FAN MingQi, JIA WeiSheng，FENG JiaYu, XIAO Ya, FANG ZhenQiang, HUANG ChiBing, ZHANG YinPu

    Department of Urinary Surgery, Second Hospital, Third Military Medical University, Chongqing 400037, China

    【Abstract】 AIM: To determine the association between urine transforming growth factor β1(TGFβ1)concentration in early posttransplant time and longterm renal allograft function. METHODS: Blood and urine TGFβ1 concentrations were tested in renal recipients who had had kidney transplantation for one year and whose renal functions were normal from August 1, 1999 to April 30, 2001. One hundred and twentysix cases completed the 3year followup. Correlation between their renal functions (creatinine clearance rates, Ccr) and their urine TGFβ1 relative concentrations after 1 year of renal transplantation were determined. Losses of Ccr and numbers of renal dysfunction in groups with different urine TGFβ1 concentrations were compared. Of the 126 cases, 15 renal recipients were diagnosed as chronic allograft nephropathy (CAN). Their blood and urine TGFβ1 concentrations and other factors after 1 year of renal transplantation were compared with those of the normal renal recipients who had no CAN. RESULTS: Urine TGFβ1 relative concentrations after 1 year of renal transplantation in the 126 patients mentioned above were 138.1-437.5 ng/g. There was a positive correlation between the longterm renal functions (Ccr) and the urine TGFβ1 relative concentrations after 1 year of renal transplantation. The patients with higher urine TGFβ1 concentration 1 year after renal transplantation had more loss of Ccr in the next 3 years than those with lower urine TGFβ1 concentration. One year after renal transplantation, the urine TGFβ1 concentrations of CAN and noCAN recipients were (184.4±38.7) and (399.0±37.5) ng/g respectively, with significant difference. The blood TGFβ1 concentrations of CAN and no CAN recipients were (33.3±5.4) and (32.7±5.1) μg/L respectively, with no significant difference. CONCLUSION: TGFβ1 may play an important role in CAN. Urine TGFβ1 is significantly higher before renal dysfunction in patients with CAN. The level of urine TGFβ1 in early stage after renal transplantation can be used to predict the longterm renal function. ......

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