Clinical observation on the anesthetic effect of propofol during gastrointestinal endoscopy

    LI Mengª²Meng£¬ZHANG Yingª²Min£¬ZHANG Jinª²Rong£¬HAO Jianª²Hua

    Department of Anesthesiology, 304th Clinical Division of PLA General Hospital, Beijing 100037, China

    ¡¾Abstract¡¿ AIM: To observe the anesthetic effect and safety of propofol during gastrointestinal endoscopy. METHODS: Six hundred and fiftyª²eight cases receiving gastrointestinal endoscopy were enrolled in this prospective study and were randomized into 3 groups: group P [228 cases received only propofol (1-1.5 mg/kg) iv], group LEP [200 cases received lidocaine 20 mg and ephedrine 6 mg followed with propofol (1-1.5 mg/kg) iv] and group C as control [230 cases has endoscopy routinely and consciously with no anesthetic whatever]. The BP, HR and SpO2 were monitored at preª², during and 5 min after endoscopy and the pain of injection, endoscopy time, awake time and satisfaction degree were recorded. RESULTS: As compared with those preª²endocsopy, the greatest changes of HR and BP in group P and C during endoscopy decreased by 20.0%-30.0% or increased by 10.0%-30.0% respectively. The changes of HR and BP in group LEP were much lesser, with the BP decreasing by 3.0% and HR increasing by 7.0%. There was significant difference between group LEP and group P and C(P<0.05). The pain during administration of propofol was more severe in group P (185 cases, 81.5%) than in group LEP (28 cases, 14.0%)(P<0.05). CONCLUSION: Administration of propofol combined with a little dosage of lidocaine and ephedrine in advance is beneficial for gastrointestinal endoscopy. This method is safe and feasible for rapid onset of sedation with minimal cardiovascular responses. This method also reduces the pain of injection. ......