Clinical significance of changes of Dª²D, tª²PA and PAI in acute renal failure patients

    TENG Yan, XUE Wuª²Jun, ZHANG Yan, JIANG Hongª²Li, XIANG Heª²Li

    1Nephropathy Center, First Hospital, Xi¬ðan Jiaotong University, 2Department of Blood Typing, Blood Center of Shaanxi Province, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To investigate the clinical significance and the changes of coagulation and fibrinolysis function in acute renal failure patients. METHODS: The level of plasma Dª²D and the activity of tissueª²type plasminogen activator (tª²PA) and plasminogen activator inhibitor (PAI) were determined in 37 acute renal failure (ARF) patients while those of the healthy people were used as control. RESULTS: ¢Ù The plasma Dª²D level and the PAI activity in ARF patients were obviously higher and the tª²PA activity was lower than those in control group(P<0.05). ¢ÚSignificant difference of the above changes was also found in postª²renal failure groups, preª²renal and renal failure groups and between simple ARF patients and renal failure patients combined with multiple organ dysfunction syndrome (MODS)(P<0.05). CONCLUSION: There was a disorder of coagulation and fibrinolysis system in ARF patients. ARF, caused by ischemic and toxicosis or combined with MODS, has the greatest effect on the changes on coagulation system. Plasma Dª²D, tª²PA and PAI can be used clinically as effective and sensitive markers reflecting the abnormal changes of coagulation and fibrinolysis system. ......