联合检测CA19-9和CA125鉴别良恶性腹水
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缪应雷, 施丕华, 段丽平
蛋白质芯片;肿瘤标志物;腹水,缪应雷,段丽平,施丕华,通讯作者:,电话:,收稿日期:,接受日期:,Valueofcombineddete
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缪应雷, 段丽平, 昆明医学院第一附属医院消化内科 云南省昆明市 650031
施丕华, 昆明医学院 云南省昆明市 650032
通讯作者: 缪应雷, 650032, 云南省昆明市, 昆明医学院第一附属医院消化内科. myldu@sina.com.cn
电话: 0871-6468574
收稿日期: 2005-11-30 接受日期: 2006-01-21
Value of combined detection of CA19-9 and CA125 in differential diagnosis between benign and malignant ascites
Ying-Lei Miao, Pi-Hua Shi, Li-Ping Duan
Ying-Lei Miao, Li-Ping Duan, Department of Gastroenterology, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
Pi-Hua Shi, Kunming Medical College, Kunming 650032, Yunnan Province, China
Correspondence to: Ying-Lei Miao, Department of Gastroenterology, the First Affiliated Hospital of Kunming Medical college, Kunming 650032, Yunnan Province, China. myldu@sina.com.cn
Received: 2005-11-30 Accepted: 2006-01-21
Abstract
AIM:To investigate the significance of cancer antigen-125 (CA-125) and CA19-9 combined detection in the differential diagnosis of benign and malignant ascites.
METHODS:A total of 59 patients were included in the study and divided into two groups based on the benignancy and malignancy. The levels of CA-125 and CA19-9 were detected in serum and ascitic fluid by protein chip technique.
RESULTS:The levels of CA125 and CA19-9 in ascitic fluid were 602.03 ± 405.72 and 370.65 ± 490.01 in malignant group, which were significantly higher than those in benign group (P <0.05). The level of serum CA125 was not markedly different between malignant and benign group, while CA19-9 level in malignant group (65.80 ± 117.45) was significantly higher than that in benign group (P < 0.05). The specificity, sensitivity and accuracy of ascitic CA19-9 in the diagnosis of malignant diseases were 66.7%, 46.2%, 57.7%, and those of ascitic CA125 were 57.6%, 61.5% and 59.3%, respectively. The specificity, sensitivity and accuracy of combined detection of CA19-9 and CA125 were 57 ......
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