【摘要】 目的 观察血友病合并艾滋病和慢性丙肝感染者用高效抗逆转录病毒治疗(HAART)3年的副作用。方法 对43例血友病合并艾滋病和慢性丙肝感染者的病人用高效抗逆转录病毒治疗3年。定期采用流式细胞仪检测CD4、CD3、CD8、NK计数; FDA批准的病毒载量仪(bDNA)检测血浆病毒载量进行随访。结果 43例病人在治疗3年后CD4+平均上升257/mm3(P<0.001)，HIV RNA下降，治疗后平均2.26±1.10log/ml(P<0.0001)。治疗后ALT、CG、IV.C上升(P<0.05)。结论 HAART能快速抑制HIV RNA的复制，但是对肝脏是有影响的。

    【关键词】 血友病合并艾滋病和慢性丙肝；高效抗逆转录病毒治疗； 副作用

    Observation for HAART side effect in the patient with hemophilia HIV/HCV co- infection within three years

    SUN Hong-qing, CHEN Liang, HUANG Qin,et al.

    Public Health Center Affiliated to Fudan University,Shanghai 201508，China

    【Abstract】 Objective The goal to observe the hemophilia patients with HIV/HCV co-infection using HAART side effect within three years.Methods 43 cases of HIV/HCV co-infection received the HAART for three years. Regularly we use flows type cell meter to examine CD4+, CD3+, CD8+, NK cell counts. The blood plasma virus load was tested by FDA authorization viral load meter (bDNA) and all patients were carried on during follow-up.Results Of 43 patients after three years of treatment CD4+ average counts rise to 257/mm3 (P<0.001), HIV RNA concentration decreased, after HAART average value reduced to 2.26±1.10log/ml (P<0.0001). But serum ALT, CG and the IV-C level were risen (P<0.05).Conclusion HAART can rapidly suppress HIV RNA replication, but it is influenced to the liver. ......