纤维_____PDGFAB；成纤维细胞；αSM

PDGFAB对成纤维细胞表达αSM actin的影响

http://www.100md.com 《第四军医大学学报》 2006年第2期

纤维,,PDGFAB；成纤维细胞；αSM,actin,PDGFAB对成纤维细胞表达αSMactin的影响,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of PDGFAB on αSM actin expression of fibroblasts

    DONG MaoLong, HU DaHai, YAO QingJun, HAN JunTao, ZHU XiongXiang

    Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the effect of PDGFAB on αSM actin expression of fibroblasts and to investigate the mechanism by which PDGFAB promotes wound healings. METHODS: In vitro cultured human normal skin fibroblasts were applied to measure the effect of PDGFAB on αSM actin expression by immunohistochemistry (SABC). RESULTS: PDGFAB could enhance αSM actin expression in a dosedependent manner. CONCLUSION: PDGFAB may promote wound healing through stimulating wound contraction by enhancing αSM actin expression of fibroblasts and stimulating fibroblasts to transform into myofibroblasts.

    【Keywords】 PDGFAB; fibroblasts; αSM actin

    【摘要】目的：研究PDGFAB对成纤维细胞表达αSM actin的影响,探讨PDGFAB促进伤口愈合的作用机制. 方法：取体外培养的人正常皮肤成纤维细胞 ......

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