关键词: 受体，甲状腺激素;糖尿病;白细胞

    摘 要:目的 了解T3 核受体介导的T3 反应在糖尿病患者外周血白细胞中的表达. 方法 应用半定量RT-PCR法，将30例糖尿病患者分为无并发症组(A组)、急性并发症组(B组)及慢性并发症组(C组)，观察各组T3 核受体(T3 R)各亚型mRNA变化. 结果 糖尿病患者外周血白细胞中T3 Rα1 ，T3 Rα2 mRNA表达增强(P<0.05)，T3 Rβ1 ，T3 Rβ2 mRNA变化不大.B，C两组这种变化显著(P<0.05). 结论 在外周血白细胞中，T3 R mRNA各亚型表达与糖尿病患者低T3 综合征密切相关.

    Expression of thyroid hormone receptor mRNA in peripheral leukocytes in DM

    LI Xiao-Miao HU Yuan-Hui LI Yuan XIE Yong-Hong

    1 Department of Endocrinology，

    2 Department of Anesthesiology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，

    3 Department of Respiratory，Tangdu Hospital，Fourth Military Medical University，

    4 Department of Pathophysiology，Chinese Traditional Medicine U-niversity of Beijing

    Keywords:receptors，thyroid hormone;diabetes mellitus;leukocytes

    Abstract:AIM To observe the relationship between the T3 R mRNA expression in diabetes mellitus(DM).METH┐ODS By using semi-quantitative RT-PCR method ......