关键词: 层粘连蛋白;受体，层粘连蛋白;宫颈肿瘤;肿瘤浸润;肿瘤转移

    摘 要:目的 探讨层粘蛋白及受体在人宫颈癌中表达及其临床意义. 方法 应用SABC免疫组化法检测20例正常宫颈组织，26例宫颈原位癌，21例宫颈浸润癌Ⅰ-Ⅱ级，18例宫颈浸润癌Ⅲ级组织中层粘蛋白及受体的表达. 结果 层粘蛋白在正常宫颈组织及原位癌中强表达，在宫颈浸润癌中间断或缺失，二者有显著性差异(P<0.05).层粘蛋白受体在正常宫颈组织及原位癌中阴性表达，在宫颈浸润癌中呈强阳性表达.有显著性差异(P<0.05). 结论 层粘蛋白及受体在人宫颈浸润癌组织中有显著性改变，可为宫颈癌病理诊断及预后判断的标志.

    Expressions and significance of laminin and laminin┐receptors in human cervical carcinoma

    LIU Chen XIN Xiao-Yan ZHANG Yu

    1 Department of Obstetrics and Gynaecology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，

    2 Shaanxi Maternity&Child Health Care Hospital

    Keywords:laminin;receptors，laminin;cervix neoplasms;neoplasm invasiveness;neoplasm metastasis

    Abstract:AIM To investigate the expressions and singnifi-cance of laminin and laminin-receptors in human cervical car┐cinoma.METHODS Tissues from normal cervices，26cases with carcinoma in situ，21cases with microinvasive cancer and18cases with frankly invasive cancer were observed by SABC immunohistochemical method for expressions of laminin and laminin-receptors.RESULTS The positive staining for laminin was observed in normal cervical tissues and carcinoma in situ ......