Hemodynamic effect of sodium nitroprusside pretreatment for tracheal intubation in renal hypertensive dogs

    WANG Jun, ZHANG Wei, WANG Jingª²Wei, CAO Yan

    1Department of Anesthesiology, Shaanxi Provincial Corps Hospital, Chinese People¬ðs Armed Police Forces, Xi¬ðan 710054, China, 2Health Center, PLA 62160 Unit, Xi¬ðan 714204, China

    ¡¾Abstract¡¿ AIM: To evaluate the preventive effect on the hemodynamic stress with the pretreatment of sodium nitroprusside followed by tracheal intubation in renal hypertensive dogs. METHODS: Four dogs with renal hypertension were enrolled in the autoª²control experiment. The dogs were anesthetized by sodium pentobarbital injection (30 mg/kg) and then tracheal intubation was performed without sodium nitroprusside pretreatment. Three days later, the same dogs were given sodium nitroprusside (8 ¦Ìg/kg¡¤min) via femoral vein before intubation. In the absence or presence of sodium nitroprusside pretreatment, their blood pressure and heart rate were measured at several time points, such as exposing glottis, inserting tube and completing intubation. The data under the two different conditions were compared by t test. RESULTS: There was significant difference in blood pressure with and without sodium nitroprusside at the time point of exposing glottis, inserting tube and completing intubation (P<0.05), while no difference was observed in heart rate. CONCLUSION: Sodium nitroprusside pretreatment can prevent the rise of blood pressure and reduce the hemodynamic stress in the process of tracheal intubation. ......