关键词: 镇痛，患者控制;手术后恶心呕吐/预防和控制;氟哌利多

    摘 要:目的 探讨不同剂量氟哌利多(droperidol)在术后吗啡患者自控镇痛(patient controlled analgesia，PCA)治疗中对恶心、呕吐的预防作用. 方法 120例ASAⅠ-Ⅲ级择期胸部手术患者用镇痛泵行静注吗啡PCA术后镇痛，随机双盲法分为4组，Ⅰ组为单纯吗啡组，40mg吗啡用生理盐水稀释至100mL(对照组);Ⅱ组为吗啡液中加入氟哌利多2.5mg(25mg·L-1 );Ⅲ组为吗啡液中加入氟哌利多5mg(50mg·L-1 );Ⅳ组为吗啡液中加入氟哌利多10mg(100mg·L-1 ).观察各组镇痛后24h内恶心、呕吐的发生率，记录吗啡用量、疼痛评分及恶心、呕吐、镇静评分. 结果 与对照组相比，只有Ⅲ，Ⅳ组恶心、呕吐发生率明显降低(P<0.05)，但较大剂量氟哌利多(Ⅳ组)使患者镇静的发生率升高(P<0.05). 结论 中等剂量氟哌利多(50mg·L-1 ，0.125mg·mg-1 吗啡)可以有效预防静注吗啡PCA所致的恶心、呕吐的发生，且不良反应较少.

    Prophylactic effects of different dosage of doperidol on nausea and vomiting during morphine patient controlled analgesia

    GAO Chang-Jun，CHAI Wei，YANG Yong-Hui，ZHAO Hui，SUN Xu-De

    Department of Anesthesiology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:analgesias patient-controlled;postoperative nau-sea and vomiting/prevention&control;droperi-dol

    Abstract:AIM To investigate the antiemetic effects of dif-ferent dosage of droperidol during morphine patient con-trolled analgesia.METHODS 120ASA physical statusⅠ-Ⅲpatients ......