关键词: 哮喘;感觉神经节;P物质;免疫组织化学

    摘 要:目的 探讨豚鼠哮喘后颈静脉节和结状节P物质(SP)表达变化. 方法 成年雄性豚鼠随机分为正常组和哮喘组，采用免疫组织化学法观察豚鼠颈静脉节和结状节SP免疫反应神经元的变化. 结果 哮喘组颈静脉节和结状节SP免疫反应神经元数量发生了显著变化，哮喘组与正常对照组比较颈静脉节和结状节SP免疫反应神经元数量显著增加(P<0.01). 结论 哮喘发病与颈静脉节和结状节SP免疫反应神经元密切相关，可能是导致哮喘持续发病的原因之一.

    Changes in SP immunoreactive neurons in the sen┐sory ganglion of asthmatic guinea pigs

    CHU Dong-Ling SONG Jun-Feng RAO Zhi-Ren QIU Jian-Yong

    1 Department of Respiratory Disease，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China，

    2 Institute of Neurosciences of Chinese PLA，Fourth Military Medical University

    Keywords:asthma;sensory ganglion;substance P;immuno-histochemistry

    Abstract:AIM To investigate the changes in SP immunore-active neurons in the jugular tubercle and nodose ganglion of asthmatic guinea pigs.METHODS Immunohistochemistry was used in this study.RESULTS There was a significant increase in the numbers of SP immunoreactive neurons in the jugular tubercle and nodose ganglion of asthma group(P<0.01).CONCLUSION There is close relationship between SP immunoreactive neurons in the jugular tubercle or nodose ganglion and attack of asthma.It may be a reason for persis-tence and progress of asthma. ......