胃黏膜内类癌合并印戒细胞癌伴胃壁胰腺组织异位的临床病理观察
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杨 琳, 张宏图, 张 洵, 孙耘田, 苏 勤
异位胰腺组织;类癌;印戒细胞癌;胃肿瘤;内分泌细胞增生,杨琳,张宏图,张洵,孙耘田,苏勤,杨琳,Coexistenceofcarcino
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杨琳, 张宏图, 张洵, 孙耘田, 苏勤, 中国医学科学院中国协和医科大学肿瘤医院病理科 北京市 100021
杨琳, 2003年获中国医科大学硕士, 现从事肿瘤病理诊断及研究工作.
国家自然科学基金资助项目, No.30171052和No.30572125
通讯作者: 苏勤, 100021, 北京市, 中国医学科学院中国协和医科大学肿瘤医院病理科. q.su@wjgnet.com
电话: 010-87788435
收稿日期: 2005-12-28 接受日期: 2006-02-08
Coexistence of carcinoid, signet-ring cell carcinoma and heterotopic pancreas in stomach: a clinicopathological observation
Lin Yang, Hong-Tu Zhang, Xun Zhang, Yun-Tian Sun, Qin Su
Lin Yang, Hong-Tu Zhang, Xun Zhang, Yun-Tian Sun, Qin Su, Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Supported by National Natural Science Foundation of China, No. 30171052 and No. 30572125
Correspondence to: Dr. Qin Su, Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. q.su@wjgnet.com
Received: 2005-12-28 Accepted: 2006-02-08
Abstract
AIM: To report a case with synchronous occurr-ence of carcinoid, signet-ring cell carcinoma (SRC) and heterotopic pancreas in stomach.
METHODS: One male patient aged 63 years old was diagnosed with coexistence of carcinoid, signet-ring cell carcinoma and heterotopic pancreas in stomach by gastroscopy and pathological examination. These three lesions were further observed by histopathological, histochemical and immunohistochemical approaches, with the related literatures reviewed.
RESULTS: Multiple foci of proliferative endocrine cells were found in lamina propria of the corpus, and carcinoid was found in corpus on the greater curve of the stomach, with muscularis mucosae involved. The tumor cells were strongly positive for neuron-specific enolase, synaptophysin and chromogranin A. An intramucosal SRC lesion was found in the lesser curve of corpus. Heterotopic pancreatic tissue was observed in muscularis propria of the antrum on the lesser curve, with hyperplasia of endocrine cells producing multiple pancreatic hormones ......
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