【摘要】 目的 探讨中晚期原发性肝癌介入治疗联合应用双灵固本散的增效保护作用。方法 将122例中晚期肝癌患者随机分成治疗组(62例)和对照组(60例)，治疗组在介入治疗前1周开始服用双灵固本散，连续15天；对照组在介入治疗后西药常规护肝治疗。两组分别在介入治疗前和第3次介入治疗后检测ICGR 15，观察栓塞后综合征。结果 治疗组在肝肿瘤缩小及减少、减轻合并症、疗效方面与对照组比较(P<0.01)；治疗组与对照组近期疗效比较差异有显著性(P<0.05)；两组AFP值的变化对照比较差异有显著性(P<0.05)；累计生存率影响两组差异有非常显著性(P<0.01)；治疗组在减轻原发性肝癌介入化疗毒副反应及栓塞综合征与对照组比较差异有非常显著性(P<0.01)；ICGR 15比较(P<0.01、P<0.05)。结论 双灵固本散在肝癌介入治疗中有显著的增效保护作用，对提高中晚期肝癌介入治疗疗效、延长生存期有重要的临床价值，临床应广泛推广。

    【关键词】 双灵固本散；介入治疗；肝癌；疗效；生存期

    The effect of sunrecome combining the interventional therapy in the treatment of hepatic tumor patients

    REN Wu-sheng,CHEN Jin-sheng,JIANG Yong-jian.

    Cancer Hospital, Affciated to Neimenggu Medical Cllege 010010,China

    【Abstract】 Objective To explore the synergic and protective effect of Sunrecome combined with the interventional radiation treatment in primary liver cancer patients in their middle and advanced stage.Methods 122 primary liver cancer patients in the middle and advanced stage were randomly divided into 2 groups, with 62 patients in treatment group,60 patients in control group. One week before the intervention, the treatment group begun to take Sunrecome for a consecutive 15 days; the control group were treated with conventional medicine therapy after intervention. ICGR 15 was tested before the intervention and after the third intervention therapy and post-catheter syndromes were observed.Results The narrowing of the liver tumor and the alleviation of complications in the treatment group compared with the control group is P<0.01, the short-term efficcay in the treatment group compared with that in the control group is P<0.05; the estimated change of AFP in the two groups is P<0.05； there is remarkable difference in the total survival rate between the two groups with P<0.01; the alleviation of toxic and side effects caused by the chemical intervention for the primary cancer patients and embolizaition when compared with that in the control group is P<0.01; ICGR 15 compared in the two groups is P<0.01 and P<0.05 respectively.Conclusion Sunrecome showed distinctive synergic and protective effect when combined with the interventional therapy for the treatment of cancer patients, and it will have a wide clinical application in improving the efficacy of the interventional treatment for the middle and late stage liver tumor patients and extending their survival rate. ......