[摘要] 缺氧诱导因子.1(HIF.1)是调节缺氧反应基因的一个核转录因子，由α和β两种亚基组成，在肿瘤血管生长、转移中起重要的作用。本文就HIF.1的结构和功能与活性调节及参与信号转导作用等方面的研究进展作一综述。

    [关键词] 缺氧诱导因子.1;血管内皮生长因子;信号转导;肿瘤血管

    Hypoxia-inducible factor-1and tumour angiogenesis

    ZHANG Wei，ZHANG Li-da，HUANG Pei-lin

    (Department of Pathology and Pathophysiology，School of Basic Medical Science，Southeast University，Nanjing210009，China)

    Abstract:Hypoxia-inducible factor-1(HIF.1)as a transcriptional activator in response to hypoxia is composed of HIF.αand HIF.βsubunits.HIF.1has been taken as a key factor in tumour angiogenesis and metastases.This review presents a summary of the structure and function of HIF.1α，and correlation among specific regulators and their signaling pathways.

    Key words:hypoxia-inducible factor-1;vascular endothlial growth factor;signaling transduction;tumour angio-genesis

    肿瘤的缺氧状态可诱导与血管形成有关的多种细胞因子释放，促进肿瘤的生长和转移。研究表明，血管内皮生长因子(vascular endothelial growth factor，VEGF)是肿瘤诱导产生新生血管的最重要的细胞因子，缺氧诱导因子1(hypoxia-inducible fac-tor-1，HIF.1)则可在基因水平上直接调控VEGF的表达，是恶性肿瘤诱导新生血管形成的一个主要调控因子。

     1 HIF.1结构

    HIF.1是一种异源二聚体转录因子，由HIF.α和HIF.β亚基组成 ......